Sunthetics partnered with Boehringer Ingelheim to develop frugal sampling strategies that explore broad chemical spaces using only 25% of the experiments required by traditional full factorial designs. The approach was validated across four metal-catalyzed cross-coupling reactions and, in one case study, was paired with SuntheticsML's Bayesian optimization to identify cost-effective reaction conditions.

Bayesian optimization enables faster, more efficient experimental design in chemical and pharmaceutical R&D by adapting each experiment based on prior results. Unlike traditional DOE, it excels in data-scarce, high-dimensional, and noisy environments—common in real-world process development. However, applying it in practice introduces challenges, including limited data, experimental noise, mixed variable types, and high experimental costs. A hybrid approach combining BO and DOE often delivers the most effective results.

Design of Experiments has been the backbone of pharmaceutical R&D for decades and for good reason. But as formulation complexity grows and experimental budgets tighten, understanding where DOE breaks down is as important as knowing how to run it.

A new peer-reviewed study in Chimica Oggi – Chemistry Today showcases how scientists used SuntheticsML to model and optimize spray freeze drying and dynamic lyophilization. The platform enabled predictive modeling, faster insights, and smarter experimentation—advancing AI-driven innovation in pharmaceutical manufacturing.

Sunthetics and Merck received the 2025 ACS Green Chemistry Award for their work on APO, a machine learning platform that streamlines pharmaceutical R&D. By reducing waste and speeding up development, APO marks a major step toward smarter, more sustainable innovation.

SOC 2, or Service Organization Controls 2, is a framework governed by the American Institute of Certified Public Accountants (AICPA). Through a SOC 2 audit, an independent service auditor reviews an organization’s policies, procedures, and evidence to determine if their controls are designed and operating effectively. A SOC 2 report communicates a company’s commitment to data security and the protection of customer information.